Sickle cell disease is the most common inherited blood disorder in the United States. The complications of sickle cell disease – pain, infections, damage to organs (kidneys, lungs, brain), anemia – can be managed with proper medical care. However, such medical care is not always available for people with the disease. Adults with sickle cell disease in particular very often have a hard time finding healthcare providers who are well-prepared to take care of them. This can lead to serious complications that could have been prevented, including early death. The Pacific Sickle Cell Regional Collaborative strives to change that by making provider training about sickle cell disease more available; testing new models for delivering care in clinics and hospitals; and testing different approaches that encourage providers to use proven therapies and guidelines for sickle cell disease care. We include the voice of people with sickle cell disease, their families and their community supporters as we address all of our goals.